How to Beat Bio–Weapon Brutal Mode in Plague Inc.
Choose your genes., Buy some initial upgrades., Choose a starting country., Evolve essential upgrades., Devolve random symptoms., Evolve your second set of upgrades., Wait for the world to get infected., Activate the Annihilate gene., Slow the...
Step-by-Step Guide
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Step 1: Choose your genes.
When starting the game, you will be able to choose a few upgrades for your virus.
What you choose here will have a huge impact on how the game plays out, so choose wisely.
There are a few suggested upgrades that you should pick to make this game easier:
DNA Gene
- ATP Boost.
This will give you extra DNA points at the beginning.
Travel Gene
- Aquacyte.
Basically required to infect difficult islands like Greenland, Iceland, and New Zealand.
Evolution Gene
- Patho-Stasis.
This will make your upgrades much cheaper.
Mutation Gene
- Genetic Mimic.
This slows the cure progression, offsetting the negative effects of the Patho-Stasis upgrade.
Environment Gene
- Extremophile.
This boosts the infection rate in every environmental condition. -
Step 2: Buy some initial upgrades.
Before choosing a starting country, use your ATP Boost bonus to purchase a few starting upgrades.
These upgrades will increase ineffectiveness while keeping lethal mutations from showing up too early.
Coughing Gene Compression 1 and 2 , Your starting country is very important, as this will determine how quickly the virus starts spreading.
Most guides recommend starting in India due to the large population and proximity to China, though others suggest Saudi Arabia.
Work will begin on the cure shortly after the game begins. , At the start of the game, you should prioritize certain upgrades to give you a much better chance later on.
As you start collecting DNA, evolve the following upgrades, in order as soon as you can afford them:
Water 1 Air 1 Gene Compression 3 Deactivated Modified Genes
- This combined with Gene Compression 3 will slow the lethal effects down significantly.
Water 2 Air 2 , Occasionally, your virus will randomly mutate.
It's highly recommended that you devolve these symptoms as they appear, as they can start killing people before the infection spreads to everyone. , This next set of upgrades is designed to greatly increase the infectivity of your virus.
Evolve these in order as soon as your have the DNA to afford them:
Cold Resistance 1 Extreme Bioaerosol Cold Resistance 2 Drug Resistance 1 and 2 If people start dying from your virus during this period, get Deactivated Modified Genes 2 as soon as possible. , At this point, you need to wait for everyone on the planet to be infected with the virus.
Once you receive the message that there is no one healthy left, you're ready to flip the switch on the virus.
If people start dying while you're waiting for everyone to get infected, get Nucleic Acid Neutralisation
1.
If more people keep dying, evolve Nucleic Acid Neutralisation
2.
If it kills again, evolve Nucleic Acid Neutralisation
3.
You will need to unlock the three Nucleic Acid Neutralisation abilities no matter what, so you may as well get them while you're waiting for everyone to get infected. in order to unlock the Annihilate gene.
Remember to keep devolving any random mutations that pop-up.
Your only symptoms should be Coughing, Rash, Cysts, Sneezing, or Sweating. , This is the ultimate symptom, and will start killing people incredibly quick.
It is essential that everyone in the world be infected before you activate this gene. , At this point, everyone in the world is going to die, unless the cure arrives first.
Your only remaining challenge is to ensure that the cure does not get finished.
The following abilities will put a serious damper on the cure's progress:
Genetic Hardening 1 and 2 Insomnia Paranoia Seizures Insanity Inflammation Paralysis Coma , If the cure is still progressing, upgrade Genetic ReShuffle 1 and
2. it shouldn't take much to watch the whole world burn at this point! -
Step 3: Choose a starting country.
-
Step 4: Evolve essential upgrades.
-
Step 5: Devolve random symptoms.
-
Step 6: Evolve your second set of upgrades.
-
Step 7: Wait for the world to get infected.
-
Step 8: Activate the Annihilate gene.
-
Step 9: Slow the cure.
-
Step 10: Shuffle the genes.
Detailed Guide
When starting the game, you will be able to choose a few upgrades for your virus.
What you choose here will have a huge impact on how the game plays out, so choose wisely.
There are a few suggested upgrades that you should pick to make this game easier:
DNA Gene
- ATP Boost.
This will give you extra DNA points at the beginning.
Travel Gene
- Aquacyte.
Basically required to infect difficult islands like Greenland, Iceland, and New Zealand.
Evolution Gene
- Patho-Stasis.
This will make your upgrades much cheaper.
Mutation Gene
- Genetic Mimic.
This slows the cure progression, offsetting the negative effects of the Patho-Stasis upgrade.
Environment Gene
- Extremophile.
This boosts the infection rate in every environmental condition.
Before choosing a starting country, use your ATP Boost bonus to purchase a few starting upgrades.
These upgrades will increase ineffectiveness while keeping lethal mutations from showing up too early.
Coughing Gene Compression 1 and 2 , Your starting country is very important, as this will determine how quickly the virus starts spreading.
Most guides recommend starting in India due to the large population and proximity to China, though others suggest Saudi Arabia.
Work will begin on the cure shortly after the game begins. , At the start of the game, you should prioritize certain upgrades to give you a much better chance later on.
As you start collecting DNA, evolve the following upgrades, in order as soon as you can afford them:
Water 1 Air 1 Gene Compression 3 Deactivated Modified Genes
- This combined with Gene Compression 3 will slow the lethal effects down significantly.
Water 2 Air 2 , Occasionally, your virus will randomly mutate.
It's highly recommended that you devolve these symptoms as they appear, as they can start killing people before the infection spreads to everyone. , This next set of upgrades is designed to greatly increase the infectivity of your virus.
Evolve these in order as soon as your have the DNA to afford them:
Cold Resistance 1 Extreme Bioaerosol Cold Resistance 2 Drug Resistance 1 and 2 If people start dying from your virus during this period, get Deactivated Modified Genes 2 as soon as possible. , At this point, you need to wait for everyone on the planet to be infected with the virus.
Once you receive the message that there is no one healthy left, you're ready to flip the switch on the virus.
If people start dying while you're waiting for everyone to get infected, get Nucleic Acid Neutralisation
1.
If more people keep dying, evolve Nucleic Acid Neutralisation
2.
If it kills again, evolve Nucleic Acid Neutralisation
3.
You will need to unlock the three Nucleic Acid Neutralisation abilities no matter what, so you may as well get them while you're waiting for everyone to get infected. in order to unlock the Annihilate gene.
Remember to keep devolving any random mutations that pop-up.
Your only symptoms should be Coughing, Rash, Cysts, Sneezing, or Sweating. , This is the ultimate symptom, and will start killing people incredibly quick.
It is essential that everyone in the world be infected before you activate this gene. , At this point, everyone in the world is going to die, unless the cure arrives first.
Your only remaining challenge is to ensure that the cure does not get finished.
The following abilities will put a serious damper on the cure's progress:
Genetic Hardening 1 and 2 Insomnia Paranoia Seizures Insanity Inflammation Paralysis Coma , If the cure is still progressing, upgrade Genetic ReShuffle 1 and
2. it shouldn't take much to watch the whole world burn at this point!
About the Author
Janet Butler
Writer and educator with a focus on practical creative arts knowledge.
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