How to Beat Prion Brutal Mode in Plague Inc.
Select "ATP Boost" for the DNA Gene., Select "DNA Mimic" as the Mutation Gene., Select "Aquacyte" as the Travel Gene., Select "Urbophile" as the Environment Gene., Select "Sympto-Stasis" as the Evolution Gene., Select Saudi Arabia, China, or South...
Step-by-Step Guide
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Step 1: Select "ATP Boost" for the DNA Gene.
This ability gives you extra DNA to start out with, which is important to get the Prion infection started correctly. , This will make the Prion infection harder to cure, which will help immensely as it spreads later in the game., Aquacyte will help get Greenland infected, which is one of the most difficult places for the infection to reach., This will help your gene cross closed borders by quickly infecting major urban centers., Sympto-Stasis will lower the cost of symptoms, allowing you to quickly reach the symptoms that will help you the most.
It makes the disease easier to cure, but you'll be making it lethal that the last second, which will kill everyone before a cure can be found.
This strategy relies on building a large list of symptoms quickly., These are the most popular starting countries for Prion, and will result in the best spread for your infection., In this initial portion of the game, you'll want to focus on symptoms that will spread your disease, as they'll be cheaper than purchasing transmission upgrades.
Focus on getting the following symptoms as soon as you can:
Rash Nausea Sweating Vomiting Cysts Hyper Sensitivity Abscesses Coughing Pneumonia Sneezing , Upgrade the following three transmissions to help get your infection spread to Greenland and Madagascar:
Water 1 Air 1 Water 2 , The following abilities will help ensure that you are able to get Greenland, which is the country that this plan hinges the most on, as well as some other wealthy countries like Monaco and Sweden:
Cold Resistance 1 Cold Resistance 2 Heat Resistance 1 Drug Resistance 1 Drug Resistance 2 Genetic Hardening 1 Genetic Hardening 2 , If any evolutions occur, devolve them to prevent your disease from become too deadly or too noticeable.
You'll also get a small DNA bonus.
Make sure to devolve any symptoms immediately, or your disease may get noticed sooner than you're ready for., The symptoms below will help increase the infectivity of your disease, which will give you more DNA to work with:
Pulmonary Oedema Skin Lesions , The following symptoms will help slow down work on the cure:
Insomnia Paranoia Seizures Paralysis Coma , Evolve the following three abilities to put a big hamper on the cure efforts:
Neural Atrophy 1 Neural Atrophy 2 Neural Atrophy 3 , This symptom will start killing off the hosts, but not too quickly as to end your game. it will also boost your infectivity., This will drop the progress of the cure back a few percentage points., The cure will move quickly towards the end, so you'll want to set it back if it reaches 25% or so before you move on to the final few steps.
If you are running low on DNA points, you can skip Genetic Reshuffle
2.
You should never need Genetic Shuffle
3. , If you haven't yet, you'll want to wait until every country is infected before you turn your disease into a killing machine.
When the last country is infected, wait until it has about 10,000-15,000 people infected before moving on. , Make sure your last infected country already has 10,000-15,000 people infected before you evolve this symptom.
This is going to start killing people off very quickly., This will help ensure that the disease continues to spread as it is killing people.
You'll need to have either Diarrhea or Insanity in order to get Dysentery. , This symptom will increase the lethality of your disease as you rush towards the end., If you were successful, the entire world should be infected shortly, with death catching up soon after.
You can speed things up by getting more symptoms, or evolve Genetic Reshuffle to slow the cure if necessary. -
Step 2: Select "DNA Mimic" as the Mutation Gene.
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Step 3: Select "Aquacyte" as the Travel Gene.
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Step 4: Select "Urbophile" as the Environment Gene.
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Step 5: Select "Sympto-Stasis" as the Evolution Gene.
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Step 6: Select Saudi Arabia
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Step 7: or South Africa.
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Step 8: Focus on symptoms that spread your disease.
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Step 9: Upgrade a few transmissions to help with infecting Greenland.
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Step 10: Upgrade some abilities to help take Greenland and other difficult countries.
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Step 11: Devolve anything not listed above.
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Step 12: Evolve some more serious symptoms to spread the infection..
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Step 13: Evolve some symptoms to slow the cure.
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Step 14: Evolve your Prion special abilities.
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Step 15: Evolve the Necrosis symptom.
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Step 16: Evolve the Genetic Reshuffle ability.
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Step 17: Evolve Genetic Reshuffle 2 when the cure reaches 25%.
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Step 18: Wait for all countries to be infected.
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Step 19: Evolve Total Organ Failure.
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Step 20: Evolve Dysentery.
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Step 21: Evolve Hemorrhagic Shock.
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Step 22: Wait while the world finishes getting infected and killed off.
Detailed Guide
This ability gives you extra DNA to start out with, which is important to get the Prion infection started correctly. , This will make the Prion infection harder to cure, which will help immensely as it spreads later in the game., Aquacyte will help get Greenland infected, which is one of the most difficult places for the infection to reach., This will help your gene cross closed borders by quickly infecting major urban centers., Sympto-Stasis will lower the cost of symptoms, allowing you to quickly reach the symptoms that will help you the most.
It makes the disease easier to cure, but you'll be making it lethal that the last second, which will kill everyone before a cure can be found.
This strategy relies on building a large list of symptoms quickly., These are the most popular starting countries for Prion, and will result in the best spread for your infection., In this initial portion of the game, you'll want to focus on symptoms that will spread your disease, as they'll be cheaper than purchasing transmission upgrades.
Focus on getting the following symptoms as soon as you can:
Rash Nausea Sweating Vomiting Cysts Hyper Sensitivity Abscesses Coughing Pneumonia Sneezing , Upgrade the following three transmissions to help get your infection spread to Greenland and Madagascar:
Water 1 Air 1 Water 2 , The following abilities will help ensure that you are able to get Greenland, which is the country that this plan hinges the most on, as well as some other wealthy countries like Monaco and Sweden:
Cold Resistance 1 Cold Resistance 2 Heat Resistance 1 Drug Resistance 1 Drug Resistance 2 Genetic Hardening 1 Genetic Hardening 2 , If any evolutions occur, devolve them to prevent your disease from become too deadly or too noticeable.
You'll also get a small DNA bonus.
Make sure to devolve any symptoms immediately, or your disease may get noticed sooner than you're ready for., The symptoms below will help increase the infectivity of your disease, which will give you more DNA to work with:
Pulmonary Oedema Skin Lesions , The following symptoms will help slow down work on the cure:
Insomnia Paranoia Seizures Paralysis Coma , Evolve the following three abilities to put a big hamper on the cure efforts:
Neural Atrophy 1 Neural Atrophy 2 Neural Atrophy 3 , This symptom will start killing off the hosts, but not too quickly as to end your game. it will also boost your infectivity., This will drop the progress of the cure back a few percentage points., The cure will move quickly towards the end, so you'll want to set it back if it reaches 25% or so before you move on to the final few steps.
If you are running low on DNA points, you can skip Genetic Reshuffle
2.
You should never need Genetic Shuffle
3. , If you haven't yet, you'll want to wait until every country is infected before you turn your disease into a killing machine.
When the last country is infected, wait until it has about 10,000-15,000 people infected before moving on. , Make sure your last infected country already has 10,000-15,000 people infected before you evolve this symptom.
This is going to start killing people off very quickly., This will help ensure that the disease continues to spread as it is killing people.
You'll need to have either Diarrhea or Insanity in order to get Dysentery. , This symptom will increase the lethality of your disease as you rush towards the end., If you were successful, the entire world should be infected shortly, with death catching up soon after.
You can speed things up by getting more symptoms, or evolve Genetic Reshuffle to slow the cure if necessary.
About the Author
Diane Howard
Committed to making home improvement accessible and understandable for everyone.
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